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Hydroxyproline

Hydroxyproline is one of four amino acids that are the main components of the protein collagen. Amino acids are the building blocks of proteins. Collagen consists of hydroxyproline, proline, lysine, and glycine. There are around 20 different types of collagen in the body. Depending on where it is located, collagen can appear as a gel-like substance or as a tightly-packed bundle of fibers. No matter where it occurs, collagen requires hydroxyproline to support its intertwined triple helix structure. Hydroxyproline is essential for the stability of the collagen molecule. Hydroxyproline is considered a non-essential amino acid because it need not form part of a healthy diet. The body is able to synthesize hydroxyproline from other components.

Hydroxyproline is formed through hydroxylation of the amino acid proline in the gastrointestinal tract. During this process, a bonded oxygen-hydrogen molecule attaches to the carbon atom in the proline amino acid. This hydroxylation process requires the presence of vitamin C (ascorbic acid) which is considered an essential vitamin because the body cannot produce it. Vitamin C must be ingested either as an oral supplement or as part of a healthy diet. Vitamin C is found in many fruit and vegetables, such as peppers, tomatoes, potatoes, strawberries, kiwi fruit, and citrus fruits. Vitamin C is water soluble and cannot be stored in the body. It is, therefore, essential to consume sufficient quantities of vitamin C on a daily basis. According to the Mayo Clinic, adult men should consume at least 90mg of vitamin C each day. The recommended daily intake for women is normally 75mg, though pregnant women may require 85mg per day. Women who are breastfeeding should consume 120mg of vitamin C each day.

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A lack of vitamin C in the body causes scurvy. The symptoms of scurvy include gum disease, spots, bruising, and wounds that will not heal correctly. These symptoms result from decreased hydroxylation of proline, leading to a deficiency of hydroxyproline, which makes the collagen molecule unstable. While scurvy can be fatal if left untreated, it rarely reaches such serious stages in modern times. Scurvy is easily treated simply by ingesting vitamin C.

To promote collagen production through the diet, a study published in the Journal of Cardiovascular Pharmacology in 2007 recommended combining foods rich in lysine (eggs, tomatoes, animal protein, dairy products, nuts, and seeds), proline (egg whites and wheatgerm), and vitamin C with green tea.

Healthy levels of hydroxyproline in the body support the stability of collagen, helping skin remain firm, toned, and flexible.

The protein collagen is a vital component of the subcutaneous matrix, the connective tissue that supports the skin. Collagen helps to heal wounds and rebuild the skin. The skin is constantly renewing itself and collagen is a vital part of the skin’s natural regenerative processes. As part of the aging process, collagen breaks down. This leads to sagging skin and the formation of wrinkles. Healthy levels of hydroxyproline in the body support the stability of collagen, helping skin remain firm, toned, and flexible.

Topical application of hydroxyproline can improve the condition of the skin, helping it appear more youthful. For this reason hydroxyproline is found as an ingredient in anti-aging skin creams, serums, and other skin products. Hydroxyproline can also improve the appearance of skin damaged by stretch marks. When applied topically to the skin, hydroxyproline penetrates the outer layers of the skin and supports collagen and elastin production in the subcutaneous matrix. Topically applied hydroxyproline also supports the production of epidermal keratinocytes, which are the main cells in the skin’s outer layers. Hydroxyproline also hydrates the skin by boosting production of ceramides, a type of lipid molecule. Ceramides prevent the loss of moisture from skin cells.

Topical application of hydroxyproline can improve the condition of the skin, helping it appear more youthful

Hydroxyproline also inhibits the production of elastase enzymes, which contribute to the aging process by breaking down vital elastin in the subcutaneous matrix.

Tablets containing a derivative of hydroxyproline, N-acetyl-L-hydroxyproline, reduce the inflammation and swelling caused by osteoarthritis.

Research is underway to determine whether compounds from the 4-cis-hydroxyproline group may be useful in the development of a skin whitening agent. The concept is that the product would inhibit the production of melanin or inhibit melanocyte differentiation. This type of skin whitening product could address pigmentation abnormalities that occur in the form of chloasma and sun spots. While clinical research indicates a possible use for hydroxyproline in skin whitening, these products are still in the very early stages of development.

  

Hydroxyproline Products

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Restore the appearance of youthful suppleness and elasticity.
$92.00
1oz | JM043
In Stock
 
Helps firm and revitalize eyes and lips.
$36.00
0.5oz | PY012
In Stock
 
A daytime moisturizer that leaves skin nourished, rejuvenated and lineless.
$69.00
1.7oz | YK021
In Stock
 
A must–have, this booster works to restore the skin's natural glow and elasticity.
$84.00
1oz | NF017
In Stock
Mazimizes skin's natural collagen levels to restore youthful volume and a lifted, firmer look.
$72.00
1oz | EX088
In Stock
 
De-puff, tighten and brighten the eye area.
$52.00
0.5oz | GT057
In Stock
 
A retinol treatment that improves skin tone and texture.
$62.00
0.5oz | CQ029
In Stock
 
This moisturizer keeps oil production in check while providing anti-aging benefits.
$65.00
1.7oz | KS019
In Stock
Includes three clinically proven technologies, each with a unique action to synergisticallytarget new and existing collagen.
$75.00
1oz | NS068
In Stock
 
This serum contains antioxidants and humectants that provide superior hydration.
$74.00
1oz | PH053
In Stock
 
An instant firming and contouring treatment with a unique anti-aging complex.
$44.00
1oz | DT033
In Stock
 
Antioxidants and exfoliants to help reduce the visible signs of aging.
$89.00
1.7oz | GT056
In Stock
Get both immediate and long term smoothing and regenerative results.
$95.00
0.50 | IS043
In Stock
 
This Vitamin C based serum helps to even out skin tone while preventing premature aging.
$85.00
1oz | KF136
In Stock
 
Wake up to softer, smoother more radiant skin.
$64.00
1.7oz | SY040
In Stock
 
A treatment to restore the appearance of fullness while reducing deep creases.
$120.00
1.7oz | PT232
In Stock
Firm, lift and brighten your skin with this multi-tasking day cream.
$20.99
1.6oz | OF002
In Stock
 
Perfumed body moisturizer enriched with shea butter and natural oils.
REG $35.00  NOW $23.45
16oz | PY1022
In Stock
 
Firm, lift and brighten the look of your skin with this multi-tasking night cream.
$20.99
1.6oz | OF003
In Stock
 
Skin will become measurably firmer, more resilient, and facial contours will appear tighter and more defined.
$93.00
1oz | JM029
In Stock
Instant brightening eye serum boosts collagen levels.
$55.00
0.5oz | BT133
In Stock
 
This concentrated serum helps to repair collagen breakdown.
$78.00
1oz | BT118
In Stock
 
A refreshing deep cleansing gel treatment masque.
$39.00
2.5oz | EX035
In Stock
 
Lightweight, antioxidant moisturizer reduces shine.
$55.00
1.7oz | KF157
In Stock
A moisture-intense treatment for wrinkle-smoothing, brightening and under eye dark circles.
$275.00
0.5oz | LJ021
In Stock
 
Firm, lift and brighten the look of your eyes with this hydrating cream.
$20.99
1oz | OF004
In Stock
 
A lightweight moisturizer that combines advanced peptides and neuropeptides to firm and lift skin.
$88.50
1.7oz | YD022
In Stock
 
A two-step wrinkle treatment that reduces the appearance of deep lines and wrinkles.
$98.00
0.5oz | NS070
In Stock
Pep up your eye area with this powerful treatment that lifts, firms and smoothes.
$75.00
0.5oz | EO016
In Stock
 
This formula hydrates skin while combating hyperpigmentation, breakouts and aging.
$56.00
7oz | PH065
In Stock
 
This treatment serum is formulated with proteins and plant stem cells that soften and enhance distressed skin.
$72.00
1oz | DQ061
In Stock
 
A dermatologist developed day fluid that expertly captures the power of 10% Glycolic Acid.
$42.00
1.7oz | EX110
In Stock
Lift, firm and diminish the appearance of wrinkles on the delicate skin of the neck and decollete.
$70.00
1.76 oz | LI026
In Stock
 
An ultra-hydrating body lotion with antioxidant and firming properties.
$36.00
16oz | PY729
In Stock
 
Firming body moisturizer leaves skin soft and lightly scented.
$36.00
16oz | PY1056
In Stock
 
This serum increases oxygen within the skin leaving it glowing with freshness.
$72.00
1oz | TH010
In Stock
Reduce the appearance of stretch marks and prevent new ones from forming.
$66.00
5.0oz | PM062
In Stock
 
Create visibly plumper and smoother lips.
$28.00
.27oz | MF093
In Stock
 
Neem Eye cream is healing and reduces puffiness from around the eye area.
$50.00
0.5oz | SD017
In Stock
 
Take action against signs of aging.
$48.00
1.7oz | MO242
In Stock
This lip treatment helps to boost collagen as it reduces lines and wrinkles.
$8.39
0.33oz | OF049
In Stock
 
Anti-oxidant rich moisturizer infused with a lively, fruity fragrance.
$35.00
16oz | PY1028
In Stock
 
Energizing lip enhancer, imbued with firming peptides, energizing peppermint oil and botanical stem cells.
$56.00
0.17oz | DQ088
In Stock
 
An intense body firming and toning cream.
$78.00
6.76oz | TH086
In Stock
Correct and protect a compromised skin barrier while reducing redness.
REG $145.00  NOW $137.75
1.7oz | VB014
In Stock
 
Tones skin and leaves it feeling velvety soft and smelling beautiful.
$36.00
16oz | PY336
No Longer Available
 
This serum helps your skin to maintain softness, firmness and elasticity.
$70.00
1oz | DQ002
No Longer Available
 
Revitalizes and restores the appearance of youthful suppleness and elasticity.
$89.00
1oz | JM042
No Longer Available
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