Skin Care Best Sellers

465 results

Best known for our skincare, we've spent over 20 years curating effective skincare that protects, prevents and corrects the visible signs of aging, hyperpigmentation, dark circles and more. Muse over skincare that has been tried, tested and rated 5* by you, our customers. Suitable for myriad skin types, lifestyle or concerns, our 5* products will inspire your skincare journey.

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  • Sunday Riley Good Genes All-In-One Lactic Acid Treatment 1.7oz

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $122.00
  • iS Clinical Cleansing Complex (6 oz.)

    15% off at Dermstore with code: WELCOME15

    Start your Dermstore journey with 15% off* your first order at Dermstore using code WELCOME15. *Offer valid for first time customers only. Cannot be combined with other discounts. Valid on participating products below only.
    SHOP AT DERMSTORE
    $48.00
  • SkinCeuticals Refine and Hydrate Anti-Aging Essentials Regimen with Vitamin C and Hyaluronic Acid

    Earn 5% back at Dermstore

    Become a Dermstore Rewards Member & earn 5% back every time you shop. That means you earn 5 points for every $1 you spend on ANY product, good towards any future purchase. To redeem this offer, opt into the reward program via your Dermstore account page & start earning today.
    JOIN NOW AT DERMSTORE
    $272.00
  • Elemis Pro-Collagen Cleansing Balm 100g

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $69.00
  • SkinMedica TNS Recovery Complex 1 oz (Worth $285)

    15% off at Dermstore with code: WELCOME15

    Start your Dermstore journey with 15% off* your first order at Dermstore using code WELCOME15. *Offer valid for first time customers only. Cannot be combined with other discounts. Valid on participating products below only.
    SHOP AT DERMSTORE
    $230.00
  • Embryolisse Lait Creme Concentre Moisturizer 2.54 fl oz

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $29.00
  • Obagi Medical Hydrate Luxe (1.7 oz.)

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $78.00
  • SkinCeuticals Phyto A+ Brightening Treatment Lightweight Moisturizer 1 fl. oz

    Double Points at Dermstore

    Earn double points at Dermstore's Black Friday Sale by becoming a Dermstore Rewards member. Double points = 10% back in rewards to spend on future purchases at Dermstore.com. Sign up for free by opting in on the account page. Participating products only. Black Friday Sale ends 12/2/24 at 11:59 p.m. PT.
    EARN AT DERMSTORE
    $110.00
  • BIOEFFECT EGF Plumping and Firming Serum 15ml

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $175.00
  • COSRX Advanced Snail 96 Mucin Power Essence 100ml

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $25.00
  • Avène Thermal Spring Water (10.1 oz.)

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $19.00
  • Epionce Renewal Facial Cream

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $102.00
  • Lancer Skincare The Method: Polish (120g)

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $80.00
  • SkinCeuticals MicroExfoliating Cleanser 150ml

    Double Points at Dermstore

    Earn double points at Dermstore's Black Friday Sale by becoming a Dermstore Rewards member. Double points = 10% back in rewards to spend on future purchases at Dermstore.com. Sign up for free by opting in on the account page. Participating products only. Black Friday Sale ends 12/2/24 at 11:59 p.m. PT.
    EARN AT DERMSTORE
    $35.00
  • Medik8 C-Tetra Serum 30ml

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $49.00
  • Medik8 Crystal Retinal 1 Serum 30ml

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $54.00
  • Dr Dennis Gross Advanced Retinol + Ferulic Overnight Wrinkle Treatment

    15% off at Dermstore with code: WELCOME15

    Start your Dermstore journey with 15% off* your first order at Dermstore using code WELCOME15. *Offer valid for first time customers only. Cannot be combined with other discounts. Valid on participating products below only.
    SHOP AT DERMSTORE
    $87.00
  • Peter Thomas Roth Water Drench Broad Spectrum SPF45 Hyaluronic Cloud Moisturizer 1.7 fl. oz

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $55.00
  • ALGENIST Triple Algae Eye Renewal Balm 15ml

    15% off at Dermstore with code: WELCOME15

    Start your Dermstore journey with 15% off* your first order at Dermstore using code WELCOME15. *Offer valid for first time customers only. Cannot be combined with other discounts. Valid on participating products below only.
    SHOP AT DERMSTORE
    $68.00
  • PCA SKIN Hydrator Plus Broad Spectrum SPF 30 1.7 oz

    Earn 5% back at Dermstore

    Become a Dermstore Rewards Member & earn 5% back every time you shop. That means you earn 5 points for every $1 you spend on ANY product, good towards any future purchase. To redeem this offer, opt into the reward program via your Dermstore account page & start earning today.
    JOIN NOW AT DERMSTORE
    $48.00
  • La Roche-Posay Anthelios Melt-in Milk Body and Face Sunscreen Lotion Broad Spectrum SPF 100 (Various Sizes)

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $26.99
  • Natura Bissé Inhibit Tensolift Neck Cream 50ml

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $235.00
  • Avène Cicalfate+ Restorative Protective Cream (3.3 oz.)

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $42.00
  • First Aid Beauty Ultra Repair Face Moisturizer (1.7 oz.)

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $28.00
  • Elemis Pro-Collagen Night Cream 50ml

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $170.00
  • PCA SKIN Intensive Age Refining Treatment 0.5 Percent Pure Retinol Night

    Earn 5% back at Dermstore

    Become a Dermstore Rewards Member & earn 5% back every time you shop. That means you earn 5 points for every $1 you spend on ANY product, good towards any future purchase. To redeem this offer, opt into the reward program via your Dermstore account page & start earning today.
    JOIN NOW AT DERMSTORE
    $118.00
  • Dermalogica Precleanse (150ml)

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $49.00
  • SENTÉ Dermal Repair Cream (1.7 oz.)

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $164.00
  • U Beauty The Super Hydrator 1.7 fl oz

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $168.00
  • MDSolarSciences Hydrating Sheer Lip Balm SPF30 0.15 oz (Various Shades)

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $25.00
  • DHC Silky Cotton Cosmetic Pads (80 Pack)

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $6.00
  • Elta MD Foaming Facial Cleanser Duo (Worth $64.00)

    Earn 5% back at Dermstore

    Become a Dermstore Rewards Member & earn 5% back every time you shop. That means you earn 5 points for every $1 you spend on ANY product, good towards any future purchase. To redeem this offer, opt into the reward program via your Dermstore account page & start earning today.
    JOIN NOW AT DERMSTORE
    $58.00
  • Medik8 Advanced Night Ceramide Cream 48g

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $76.00
  • Epionce Gentle Foaming Cleanser

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $36.00
  • DHC Super Collagen Supreme 50ml

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $31.00
  • Lancer Skincare The Method: Polish (Bonus Size 227g, Worth $142)

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $120.00
  • Perricone MD Hypo Nourishing Moisturizer 2oz FG

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $75.00
  • iS Clinical SHEALD Recovery Balm (2 oz.)

    15% off at Dermstore with code: WELCOME15

    Start your Dermstore journey with 15% off* your first order at Dermstore using code WELCOME15. *Offer valid for first time customers only. Cannot be combined with other discounts. Valid on participating products below only.
    SHOP AT DERMSTORE
    $79.00
  • Medik8 Liquid Peptides Serum 30ml

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $64.00
  • Colorescience Sunforgettable Total Protection Color Balm 0.32oz. (Various Shades)

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $39.00
  • SkinCeuticals Phyto Corrective Mask 60ml

    Double Points at Dermstore

    Earn double points at Dermstore's Black Friday Sale by becoming a Dermstore Rewards member. Double points = 10% back in rewards to spend on future purchases at Dermstore.com. Sign up for free by opting in on the account page. Participating products only. Black Friday Sale ends 12/2/24 at 11:59 p.m. PT.
    EARN AT DERMSTORE
    $70.00
  • ESPA Pink Pomelo Lip Balm 10g

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $28.00
  • Obagi Clinical Kinetin+ Exfoliating Cleansing Gel 5.1 fl. oz

    Obagi Clinical Dark Spot Disruptor Discoloration Correcting Serum Deluxe Sample 5ml (Worth $11.00)
    Obagi Clinical Dark Spot Disruptor Discoloration Correcting Serum Deluxe Sample 5ml (Worth $11.00) Worth $11.00

    $11 Obagi Clinical Gift

    Receive an Obagi Clinical Dark Spot Disruptor Discoloration Correcting Serum Deluxe Sample 5ml (Worth $11) when you spend $100 or more on the brand. Complimentary gift will be awarded at the cart. Offer valid for a limited time only, while supplies last.
    SHOP NOW
    $39.00
  • Epionce Purifying Wash 8oz

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $46.00
  • Alchimie Forever Kantic Brightening Moisture Mask

    Double Points at Dermstore

    Earn double points at Dermstore's Black Friday Sale by becoming a Dermstore Rewards member. Double points = 10% back in rewards to spend on future purchases at Dermstore.com. Sign up for free by opting in on the account page. Participating products only. Black Friday Sale ends 12/2/24 at 11:59 p.m. PT.
    EARN AT DERMSTORE
    $60.00
  • Replenix BP Acne Gel 10% Spot Treatment

    Up to 30% off at Dermstore

    Receive up to 30% off at Dermstore's Black Friday Sale on select brands. Participating products only. Black Friday Sale ends 12/2/2024 at 11:59 p.m. PST.
    SHOP AT DERMSTORE
    $34.00
  • IMAGE Skincare ORMEDIC Balancing Facial Cleanser 6 fl. oz

    Double Points at Dermstore

    Earn double points at Dermstore's Black Friday Sale by becoming a Dermstore Rewards member. Double points = 10% back in rewards to spend on future purchases at Dermstore.com. Sign up for free by opting in on the account page. Participating products only. Black Friday Sale ends 12/2/24 at 11:59 p.m. PT.
    EARN AT DERMSTORE
    $39.00
  • Hero Cosmetics Rescue Balm Post-Blemish Recovery Cream

    Double Points at Dermstore

    Earn double points at Dermstore's Black Friday Sale by becoming a Dermstore Rewards member. Double points = 10% back in rewards to spend on future purchases at Dermstore.com. Sign up for free by opting in on the account page. Participating products only. Black Friday Sale ends 12/2/24 at 11:59 p.m. PT.
    EARN AT DERMSTORE
    $12.99